Figure 2.
Spatial working memory involves PLC and calcineurin activities. (A) Representative Gq/11α and Na+/K+ ATPase Western blots performed on mPFC membrane extracts taken at time-points during the delay match-to-place task compared against swim controls. Summary results showing average Gq/11α immunoreactivity as a percentage of that obtained for swim controls. *P < 0.05. (B) Average latency to hidden platform for location trials and match trials during the delay match-to-place task for intra-mPFC infused vehicle and U73122 (0.26 μg). *P < 0.05 comparing location to match trials; †P < 0.05 comparing match trials between groups. (C) mPFC calcineurin activity expressed as percentage swim control at time-points during the delay match-to-place working memory task. *P < 0.05. (D) Average latency to hidden platform for location and match trials during the delay match-to-place task for intra-mPFC vehicle, and cyclosporin A (0.3 μg or 0.7 μg) animals. *P < 0.05 comparing location to match trials.