. 2003 Feb 5;100(4):2035–2040. doi: 10.1073/pnas.0337642100

Table 3.

Inhibition of aggressiveness in SI male mice and in vitro inhibition of 5-HT uptake into rat synaptosomes by FLX and NFLX stereoisomers

Drug tested	Inhibition of aggressive behavior, IC₅₀, μmol/kg	Inhibition of 5-HT uptake,^*K_i, nM
R/S-FLX	1.08 ± 0.015^†	20 ± 2
S-FLX	0.71 ± 0.03^‡	22 ± 3
R-FLX	1.3 ± 0.024	35 ± 5
S-NFLX	0.2 ± 0.08^§	14 ± 4^¶
R-NFLX	1.53 ± 0.2	309 ± 22

Data are from Wong et al. (17).

^†

P < 0.05 when R/S-FLX is compared to S-FLX or R-FLX. IC₅₀ values were calculated according to the method of Tallarida and Murray (26).

^‡

P < 0.01 when S-FLX is compared to R-FLX.

^§

P < 0.001 when S-NFLX is compared to R-NFLX and S-FLX.

^¶P < 0.001 when S-NFLX is compared to R-NFLX.