Fig. 2.
Multivariable hazard ratios and 95% confidence intervals from calibrated analyses of colorectal cancer for individual center in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Hazard ratios (HRs) per 100-g increase in intake and 95% confidence intervals (CIs) were calculated for calibrated intakes of A) red and processed meat and B) fish. Hazard ratios were calculated from β coefficients from Cox regression models adjusted for age, sex, energy from nonfat sources (continuous variable), energy from fat sources (continuous variable), height (tertiles defined for each sex and center), weight (tertiles defined for each sex and center), work-related physical activity (no activity, sedentary, standing, manual, or heavy manual) smoking status (never, former, or current smoker), fiber intake (grams per day) and alcohol consumption (grams of day). Centers with fewer than 50 case patients with colorectal cancer are not included. The black squares and horizontal lines correspond to the center-specific hazard ratios (per 100-g increase in intake) and 95% confidence intervals. The area of the square refl ects the center-specific statistical weight (inverse of the variance). The diamond and horizontal lines represent the hazard ratio and 95% confidence intervals in EPIC.