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. 2000 Jan 3;191(1):189–194. doi: 10.1084/jem.191.1.189

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© 2000 The Rockefeller University Press

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Histopathologic comparison of aortas from study animals. Sections shown are typical of the most advanced lesions found in animals of each genotype. (A) C57BL/6 wild-type murine aorta with intact intimal (top), unremarkable media (middle), and adventitial (bottom) layers with no evidence of atheromatous lesion. (B) Aorta from apo E^−/− mouse with no CAM deficiency showing well formed atheromatous plaque characterized by foam cells, cell debris, cholesterol clefts, and calcification (arrow) within the expanded intima. Lesions exhibiting the calcification seen only in very advanced lesions were only found in apo E^−/− mice with no CAM deficiency. (C) Aorta from an apo E^−/−ICAM-1^−/− animal with lesion composed of foam cells, cholesterol clefts, and extracellular lipid in expanded intima (arrow). (D) Aorta from apo E^−/− P-selectin^−/− animal with less developed atherosclerotic lesions (arrows) composed of frequent foam cells within expanded intima. Note relatively normal aortic segment between atheromatous lesions. (All hematoxylin and eosin stain with original magnification of 200).