TABLE 2.
Structure and sequence pair-wise similarities between FH and other RCA-CCPs of known structure
Domain boundaries considered from one residue before Cysl to three residues after CysIV (where available). Values on the left-hand side specify Cα r.m.s.d. values in Angstroms (Å) Values in parentheses represent the structural alignment lengths in terms of the numbers of Cα atoms for which the r.m.s.d. values were calculated. Values in italics on the right-hand side represent pair-wise percentage (%) sequence identities calculated using the Percentage Identity Matrix option under ClustalX (80).
| Factor H modules | |||
|---|---|---|---|
| RCA-CCP (PDB code (81)) | FH1 | FH2 | FH3 |
| FH 1 (2RLP) | |||
| FH 2 (2RLQ) | 3.12 (59); 27 | ||
| FH 3 (2RLQ) | 3.00 (54); 22 | 1.80 (55); 20 | |
| FB 1 (2OK5) | 4.13 (64); 20 | 2.34 (55); 19 | 2.04 (51); 32 |
| FB 2 (2OK5) | 3.35 (60); 20 | 2.20 (57); 24 | 1.80 (58); 25 |
| FB 3 (2OK5) | 3.38 (58); 23 | 1.91 (57); 23 | 1.30 (56); 26 |
| C4BPα 1 (2A55) | 2.23 (60); 27 | 3.48 (69); 24 | 3.24 (61); 19 |
| C4BPα 2 (2A55) | 3.22 (58); 22 | 1.81 (57); 31 | 1.70 (57); 24 |
| CR1 15 (1GKN) | 1.98 (58); 26 | 3.03 (59); 20 | 2.76 (55); 18 |
| CR1 16 (1GKN) | 3.38 (58); 24 | 1.57 (58); 28 | 1.67 (57); 24 |
| CR1 17 (1GKG) | 2.74 (58); 26 | 2.31 (58); 36 | 2.12 (57); 32 |
| DAF 1 (1OK3) | 2.48 (60); 22 | 2.54 (59); 15 | 2.59 (59); 17 |
| DAF 2 (1OK3) | 2.22 (61); 31 | 2.92 (60); 21 | 2.80 (59); 20 |
| DAF 3 (1H03) | 3.31 (58); 22 | 1.59 (58); 29 | 1.54 (57); 34 |
| DAF 4 (1H03) | 2.68 (58); 28 | 1.91 (57); 25 | 1.63 (58); 31 |
| MCP 1 (2CKL) | 2.56 (60); 23 | 2.73 (58); 20 | 2.73 (58); 22 |
| MCP 2 (2CKL) | 3.32 (53); 27 | 1.77 (59); 36 | 1.63 (56); 34 |
| VCP 1 (1G40) | 3.41 (61); 27 | 3.09 (59); 24 | 2.82 (60); 21 |
| VCP 2 (1G40) | 3.33 (58); 22 | 2.44 (57); 39 | 2.04 (56); 28 |
| VCP 3 (1G40) | 2.79 (58); 30 | 2.57 (58); 30 | 2.47 (56); 35 |
| VCP 4 (1G40) | 3.06 (58); 25 | 2.21 (55); 21 | 2.29 (58); 38 |