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. 2007 Oct 9;97(9):1189–1193. doi: 10.1038/sj.bjc.6604029

Figure 2.

Figure 2

Relationship between cancer and ageing. DNA damage and proto-oncogenic stress lead to activation of senescence or apoptotic programs, which may eventually deplete adult stem cell pools and degrade tissue renewal capacity. Cells that escape senescence and apoptosis are permitted to continue cell division and undergo transformation, leading to the development of cancer.