Figure 5.
BDNF+/− mice develop hyperphagia and elevated body mass. (A) Daily food intake (g/day) of BDNF+/− and WT mice (n = 12–13/group). Values indicate the mean ± SEM of daily food intake averaged over a 2-week interval. Food intake of BDNF+/− mice was significantly higher than in age-matched WT controls (ANOVA, P < 0.05). (B) Growth curves for BDNF+/− and WT mice (n = 110–115/group) indicate that BDNF+/− mice have a significantly higher body weight than WT littermates, beginning at 10 weeks of age (ANOVA, P < 0.001). (C) Body weight of 15-month-old WT, BDNF+/−, and mice heterozygous for other members of the neurotrophin (NT-3+/−) or neurotrophin receptor family (trkA+/− and trkC+/−). *, P < 0.05 compared with WT.