Figure 1. Results of primary region of interest analysis in the medial temporal lobe: increased hippocampal activation and decreased parahippocampal activation in perimenopausal initiators of hormone therapy compared to never users.
Sagittal, coronal, and axial projections of medial temporal regions showing significant (p < .01) differences in activation between perimenopausal users of hormone therapy and nonusers. Odd numbered rows show glass brain images of significant findings, and even numbered rows show activations superimposed on a structural anatomical template, with most significant voxel depicted in the cross-hairs. The scale to the right of each pair of figures shows the color scale corresponding to the z-values for that particular analysis. Rows 1 and 2 show significantly decreased activation in perimenopausal estrogen users compared to nonusers in bilateral parahippocampal gyrus. Rows 3 and 4 show significantly increased activation in perimenopausal users compared to never users in the left hippocampus during verbal recognition, and Rows 4 and 5 show a similar effect during verbal match.