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Mutation of fob1 suppresses the life span defect of a sir2 mutant. Life spans were determined for W303R, and the isogenic derivatives, sir2Δ hmlΔ, and sir2Δ hmlΔ fob1Δ. Mean life spans and the number of mothers examined were as follows: W303R 20.7 (n = 38), fob1Δ 27.0 (n = 37), sir2Δ hmlΔ 13.0 (n = 47) and sir2Δ hmlΔ fob1Δ 21.9 (n = 48). (♦) W303R; (█) fob1; (▴) sir2 hml; (×) sir2 hml fob1.
