. Author manuscript; available in PMC: 2012 Oct 12.

Published in final edited form as: Chem Rev. 2011 Jul 18;111(10):5922–5943. doi: 10.1021/cr100396c

Table 2.

Specialized Pro-resolving Lipid Mediators in Disease Models

Disease	Reference
Cardioprotective	Spite and Serhan^a
	Keyes et al.^b
Reno-protection	Hassan and Gronert¹⁰⁸
Atherosclerosis	Merched et al.^c
Corneal wound healing	Gronert et al.^d
Ocular indications	Connor et al.¹⁰³
	Li et al.¹⁰²
	Zhang et al.¹⁰⁵
Stroke	Marcheselli et al.⁸⁰
	Ye et al.^e
Ischemia-reperfusion (kidney and lung)	Duffield et al.⁹⁷
	Kasuga et al.⁵⁷
Asthma, ALI	Haworth et al.¹⁰⁶
	Fukunaga et al.^f
	Aoki et al.^g
	Hisada et al.^h
Obesity-induced insulin resistance and hepatic steatosis	Clària et al.ⁱ
Inflammatory pain	Xu et al.¹¹¹
Parturition	Maldonado-Pèriz et al.^j

Spite, M.; Serhan, C. N. Circulation Res. 2010, 107, 1170.

Keyes, K. T.; Ye, Y.; Lin, Y.; Zhang, C.; Perez-Polo, J. R.; Gjorstrup, P.; Birnbaum, Y. Am. J. Physiol. Heart Circ. Physiol. 2010, 299, H153.

Merched, A.; Ko, K.; Gotlinger, K. H.; Serhan, C. N.; Chan, L. FASEB J. 2008, 22, 3595.

Gronert, K.; Maheshwari, N.; Khan, N.; Hassan, I. R.; Dunn, M.; Schwartzman, M. L. J. Biol. Chem. 2005, 280, 15267.

Ye, X.-H.; Wu, Y.; Guo, P.-P.; Wang, J.; Yuan, S.-Y.; Shang, Y.; Yao, S.-L. Brain Res. 2010, 1323, 174.

Fukunaga, K.; Kohli, P.; Bonnans, C.; Fredenburgh, L. E.; Levy, B. D. J. Immunol. 2005, 174, 5033.

Aoki, H.; Hisada, T.; Ishizuka, T.; Utsugi, M.; Kawata, T.; Shimizu, Y.; Okajima, F.; Dobashi, K.; Mori, M. Biochem. Biophys. Res. Commun. 2008, 367, 509.

Hisada, T.; Ishizuka, T.; Aoki, H.; Mori, M. Expert Opin. Ther. Targets 2009, 13, 513.

ⁱ

Clària, J.; Titos, E.; López-Vicario, C.; González-Périz, A. Drug Discov. Today Dis. Mech. 2010, 7, e219.

Maldonado-Pèriz, D.; Golightly, E.; Denison, F. C.; Jabbour, H. N.; Norman, J. E. FASEB J. 2011, 25, 569.