Fig. 4.
(A) Body weights of 8- to 24-week-old mice. The data were collected every other week (n = 7, asterisk indicates P < 0.05 +/+ vs. -/- at 16-24 weeks). (B) Cumulative food intakes from 8 to 24 weeks of age (n = 7, P > 0.05 +/+ vs. -/- at all data points). (C and D) Changes in body weight and food intake during fasting and refeeding. Twelve-week-old mice were fasted for 24 h and then allowed to eat. Body weight was measured before and after the fasting, and at 24 h and 48 h after the food was given. Cumulative food intake was measured at 1, 2, 4, 6, 24, and 48 h after food was given (n = 6, P > 0.05 +/+ vs. -/-).