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Proposed mechanisms by which resveratrol exerts cytoprotection. (1) Resveratrol attenuates oxidative stress. (2) Resveratrol activates SIRT1, which is an NAD+-dependent deacetylase,directly or indirectly via AMPK activation. SIRT1 plays an important role in the regulation of oxidative stress, inflammation, apoptosis, stress resistance, mitochondrial biogenesis, autophagy, and glucose-lipid metabolism, via the deacetylation of many substrates.
