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Immunohistochemical staining of GRP78, p-ERK and caspase-12 in the kidney. Animals were divided into four groups: the control group (N), the cisplatin (CP) group (C), the grape seed proanthocyanidin extract (GSPE) group (G) and the CP+GSPE group (C+G). The brown granules represent positively-stained cells. Magnification, ×1,000.
