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. 2014 Jan 3;9(3):801–807. doi: 10.3892/mmr.2014.1883

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Copyright © 2014, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Semi-quantitative analysis of immunohistochemical staining of GRP78, p-ERK and caspase-12 in the kidney, based on the percentage of positively stained areas in the tubules and the intensity of staining. Animals were divided into four groups: the control group (N), the cisplatin (CP) group (C), the grape seed proanthocyanidin extract (GSPE) group (G) and the CP+GSPE group (C+G). The expression of GRP78, p-ERK and caspase-12 was significantly increased in the C group compared to the N group and significantly decreased in the C+G group compared to the C group.^*Statistically significant difference compared to the N group (p<0.05); ^#statistically significant difference compared to the C group (p<0.05).