Extended Data Table 2. Enrichments of 49 WHRadjBMI signal SNPs with metabolic and anthropometric traits.
The 49 waist-hip ratio adjusted for body mass index (WHRadjBMI) SNPs were tested for association with other traits by GWAS meta-analyses performed by other groups (see Online Methods). The maximum sample size available is shown overall or separately for 61 cases/controls. N indicates the number of the total SNPs for which the WHRadjBMI-increasing allele is associated with the trait in the concordant direction (increased levels, except for HDL-C, adiponectin, and BMI). One-sided binomial P values test whether this number is greater than expected by chance (null P = 0.5 and null P = 0.025, respectively). The tests do not account for correlation between WHRadjBMI and the tested traits. P values representing significant column-wise enrichment (P < 0.05 / 23 tests) are marked in red and bold.
| SNPs in concordant direction | SNPs in concordant direction with P < 0.05 | ||||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Trait | Max. sample size | N | Total | P | N | Total | P |
| Type 2 diabetes (T2D) | 86,200 | 37 | 49 | 2.35E-04 | 16 | 49 | 3.56E-14 |
| Fasting glucose (FG) | 132,996 | 35 | 49 | 1.90E-03 | 8 | 49 | 2.75E-05 |
| Fasting insulin adjusted for BMI (FladjBMI) | 103,496 | 45 | 49 | 4.11E-10 | 36 | 49 | 4.04E-47 |
| 2-hour glucose (G120) | 42,853 | 33 | 49 | 1.06E-02 | 7 | 49 | 2.09E-04 |
| Diastolic blood pressure (DBP) | 69,760 | 34 | 49 | 4.70E-03 | 10 | 49 | 3.21 E-07 |
| Systolic blood pressure (SBP) | 69,774 | 38 | 49 | 7.10E-05 | 6 | 49 | 1.36E-03 |
| Body mass index (BMI) | 322,120 | 40 | 49 | 4.63E-06 | 23 | 49 | 4.42E-24 |
| Height | 253,209 | 25 | 49 | 5.00E-01 | 14 | 49 | 1.10E-11 |
| High-density lipoprotein cholesterol (HDL-C) | 187,142 | 45 | 49 | 4.11E-10 | 24 | 49 | 1.22E-25 |
| Low-density lipoprotein cholesterol (LDL-C) | 173,067 | 33 | 49 | 1.06E-02 | 12 | 49 | 2.32E-09 |
| Triglycerides (TG) | 177,838 | 46 | 49 | 3.49E-11 | 29 | 49 | 6.02E-34 |
| Adiponectin | 29,347 | 41 | 49 | 9.82E-07 | 20 | 49 | 1.28E-19 |
| Endometriosis | 1,364/7,060 | 24 | 45 | 3.83E-01 | 4 | 45 | 2.58E-02 |
| Nephropathy (in Chinese subjects) | 1,194/902 | 18 | 43 | 8.89E-01 | 0 | 43 | 1.00E+00 |
| Nephropathy (in Italian subjects) | 1,045/1,340 | 20 | 43 | 7.29E-01 | 1 | 43 | 6.63E-01 |
| Estimated glomerular filtration rate of creatinine (eGFRcrea) | 74,354 | 29 | 49 | 1.26E-01 | 3 | 49 | 1.24E-01 |
| Chronic kidney disease (CKD) | 74,354 | 17 | 49 | 9.89E-01 | 2 | 49 | 3.47E-01 |
| Urine albumin-to-creatinine ratio (UACR) | 31,580 | 22 | 49 | 8.04E-01 | 2 | 49 | 3.47E-01 |
| Menopause | 87,802 | 28 | 49 | 1.96E-01 | 1 | 49 | 7.11E-01 |
| Menarche | 38,968 | 23 | 49 | 7.16E-01 | 2 | 49 | 3.47E-01 |
| Coronary artery disease (CAD) | 191,198 | 27 | 48 | 2.35E-01 | 9 | 48 | 2.64E-06 |
| Femoral neck bone mineral density (FN-BMD) | 32,960 | 25 | 49 | 5.00E-01 | 4 | 49 | 3.40E-02 |
| Lumbar spine bone mineral density (LS-BMD) | 31,798 | 28 | 49 | 1.96E-01 | 3 | 49 | 1.24E-01 |