FIG. 5.
Shortened life spans of G3 wbt and bt mice. Kaplan-Meier analysis of survival in G3 wild-type, wb, t, wt, bt, and wbt mice (new crosses) is shown. w and b single mutants had no shortening of life span for the 12 months examined, and they were omitted for clarity. Only natural deaths were counted in the analyses; data for mice harvested for analytical autopsy were censored in the analysis and are indicated as points on each line that are not associated with a drop in the fraction alive. The numbers of mice in each cohort are indicated in parentheses. By log-rank test, the G3 wbt life span was shorter than that of all other genotypes at P < 0.0001, and G3 bt life span was different from all other genotypes at P ≤ 0.002.