Table 2. Estrogen and anti-androgen options for transgender women.
| Route | Formulation | Dosing |
|---|---|---|
| Oral | Estradiol | 2–4 mg daily |
| Parental (subcutaneous, intramuscular) | Estradiol valerate | 5–30 mg every 2 weeks |
| Transdermal | Estradiol | 0.1–0.4 mg twice weekly |
| Anti-androgens | Progesterone | 20–60 mg PO daily |
| Medroxyprogesterone acetate | 150 mg IM every 3 months | |
| GnRH agonist (leuprolide) | 3.75–7.5 mg IM monthly | |
| Histrelin implant | 50 mg implanted every 12 months | |
| Spironolactone | 100–200 mg PO daily | |
| Finasteride | 1 mg PO daily |