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Microsome proliferation and induction of ω-fatty acid oxidation in Nrf1LKO livers. (a) RT-PCR analysis of mRNA encoding various enzymes associated with β- and ω-fatty acid oxidation. 18s levels were used as control. Representative electron micrograph of control (b) and Nrf1LKO (c) livers at 2 months. Note lipid droplets, smaller and darker mitochondria, and proliferation of smooth ER in the Nrf1LKO liver.
