Fig. 1.
Associations between risk of prostate cancer and increasing fifths of hormone concentrations. The position of each square indicates the magnitude of the relative risk, and the area of the square is proportional to the amount of statistical information available (inverse of the variance of the logarithm of the relative risk). The length of the horizontal line through the square indicates the 95% confidence interval. The chi-square 1 degree of freedom statistic for linear trend is calculated by replacing the categorical variables with a continuous variable scored as 0, 0.25, 0.5, 0.75, and 1. The P value was two-sided for statistical significance of the chi-square linear trend statistic. RR = relative risk; CI = confidence interval; DHT = dihydrotestosterone; DHEA-S = dehydroepiandrosterone sulfate; SHBG = sex hormone–binding globulin.