Comparison 6.
High vs low ALA omega‐3 fats (tertiary outcomes)
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Blood pressure, mmHg ‐ ALA | 4 | Mean Difference (IV, Random, 95% CI) | Subtotals only | |
| 1.1 Systolic BP ‐ ALA | 4 | 1671 | Mean Difference (IV, Random, 95% CI) | ‐0.87 [‐4.48, 2.75] |
| 1.2 Diastolic BP ‐ ALA | 4 | 1671 | Mean Difference (IV, Random, 95% CI) | ‐1.42 [‐4.40, 1.57] |
| 2 Serious adverse events ‐ ALA | 2 | Risk Ratio (M‐H, Random, 95% CI) | Subtotals only | |
| 2.1 Any serious adverse events | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 2.2 Bleeding | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 2.3 GI hospitalisation | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 2.4 Pulmonary embolus or DVT | 1 | 708 | Risk Ratio (M‐H, Random, 95% CI) | 0.32 [0.01, 7.80] |
| 2.5 Thrombophleibitis | 1 | 13406 | Risk Ratio (M‐H, Random, 95% CI) | 1.59 [0.72, 3.51] |
| 2.6 Urolithiasis | 1 | 13406 | Risk Ratio (M‐H, Random, 95% CI) | 0.80 [0.47, 1.36] |
| 3 Side effects ‐ ALA | 5 | Risk Ratio (M‐H, Random, 95% CI) | Subtotals only | |
| 3.1 Dropouts due to side effects | 5 | 3480 | Risk Ratio (M‐H, Random, 95% CI) | 2.10 [0.66, 6.71] |
| 3.2 Abdominal pain or discomfort | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 3.3 Diarrhoea | 1 | 708 | Risk Ratio (M‐H, Random, 95% CI) | 3.82 [0.82, 17.88] |
| 3.4 Nausea | 1 | 110 | Risk Ratio (M‐H, Random, 95% CI) | 6.29 [0.33, 118.93] |
| 3.5 Any gastrointestinal side effect ‐ ALA | 4 | 3450 | Risk Ratio (M‐H, Random, 95% CI) | 2.06 [0.62, 6.80] |
| 3.6 Pain (joint, lumbar, muscle pain) | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 3.7 All side effects combined | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 4 Dropouts ‐ ALA | 6 | 3663 | Risk Ratio (M‐H, Random, 95% CI) | 1.08 [0.92, 1.25] |