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The effect of exercise on Aβ load in three different brain regions of TgCRND8 mice. Exercising animals show a significant (*) reduction in Aβ immunoreactivity in the frontal cortex (p = 0.018) and cortex at the level of the hippocampus (p = 0.0003). There is also a decrease in Aβ in the hippocampus of exercising animals (p = 0.06). The photomicrograph shows a representative section from both groups. Scale bar, 200 μm. Error bars indicate ± SE.
