TABLE 3.
Proportion of IR-A mRNA and total IR content in normal and cancer specimens from human breast, lung, and colon
| Tissue (no. of specimens) | Proportion (%) of IR-Aa
|
P value | IR content (ng/0.1 μg of protein) | |
|---|---|---|---|---|
| Range | Median | |||
| Breast cancer (n = 12) | 40–80 | 73 | 3.2 ± 1.8 | |
| Normal breast (n = 12) | 30–50 | 43 | 0.005 | 0.5 ± 0.3 |
| Lung cancer (n = 6) | 30–60 | 53 | 1.1 ± 0.3 | |
| Normal lung (n = 6) | 30–55 | 39 | 0.065 | 0.5 ± 0.1 |
| Colon cancer (n = 10) | 65–80 | 68 | 1.8 ± 0.5 | |
| Normal colon (n = 10) | 30–65 | 35 | 0.01 | 1.3 ± 0.4 |
a
As determined by RT-PCR.
b
Wilcoxon signed-rank test.